Last updated on 21 February, 2025

Record statistics by species and TCR chain

General statistics. Note that general statistics are computed using the ‘slim’ database version. Slim version, for example, lists the same TCR sequence found in several donors/studies only once and selects representative V/J for a given CDR3aa clonotype and the best score across all redundant records.

Species Chain Records Paired records Unique epitopes Studies
HomoSapiens TRA 32384 32384 1060 197
HomoSapiens TRB 46962 27211 1258 253
MacacaMulatta TRB 1251 0 3 2
MusMusculus TRA 1636 1636 58 37
MusMusculus TRB 2775 1598 80 41

Record statistics by year

Number of unique TCR sequences, epitopes, MHC alleles and studies by publication year, cumulative plots.

Summary by antigen and antigen origin

Representative data for Homo Sapiens

Parent species Records Unique epitopes Studies
CMV 32846 31 47
InfluenzaA 11645 38 30
EBV 10626 33 37
SARS-CoV-2 8678 662 18
HomoSapiens 7073 315 101
HIV-1 3120 64 34
HCV 1805 22 11
Mtb 713 2 1
YFV 665 1 5
DENV 392 3 1
InfluenzaB 374 3 1
PlasmodiumFalciparum 282 6 1
TriticumAestivum 221 19 12
HTLV-1 198 2 3
SARS-CoV 142 1 1
Wheat 82 2 3
RotavirusA 80 3 1
synthetic 62 29 4
CoxsackievirusB 59 2 1
M.tuberculosis 59 11 3
HCoV-HKU1 45 1 1
HSV-2 44 1 1
E.Coli 41 3 4
HPV 26 1 1
gsiA 17 1 1
AdV 15 2 1
MCPyV 12 2 1
CryptomeriaJaponica 8 1 1
StreptomycesKanamyceticus 6 1 1
HPV-16 4 2 1
HHV 2 1 1
PseudomonasAeruginosa 2 1 1
PseudomonasFluorescens 2 1 1

COVID-19 data

Summary of antigens and T-cell receptors related to COVID-19 pandemic. Number of records for SARS-CoV-2 epitopes grouped by viral protein and HLA plotted using alluvium plot. Epitopes with less than 30 records in total were not counted.

Summary of SARS-CoV-2 epitopes and corresponding TCR alpha and beta chain specificity records (cases with 10+ records)

Gene HLA Epitope Studies TRA TRB
Spike HLA-A.02 YLQPRTFLL 9 661 891
Nucleocapsid HLA-B.07 SPRWYFYYL 4 370 520
ORF1ab HLA-A.01 TTDPSFLGRY 3 372 417
Spike HLA-DPA.01/B.04 TFEYVSQPFLMDLE 2 93 434
Nucleocapsid HLA-A.03 KTFPPTEPK 2 121 161
Spike HLA-A.24 QYIKWPWYI 5 130 144
Spike HLA-A.01 LTDEMIAQY 2 123 127
Nucleocapsid HLA-A.02 RTATKQYNV 1 50 92
Spike HLA-B.15 NQKLIANQF 1 72 70
Spike HLA-A.02 RLQSLQTYV 5 49 87
Spike HLA-A.24 NYNYLYRLF 3 56 52
Nucleocapsid HLA-B.40 MEVTPSGTWL 1 44 59
ORF3 HLA-A.01 FTSDYYQLY 2 39 38
ORF3 HLA-A.02 LLYDANYFL 3 27 40
ORF1ab HLA-A.02 ALWEIQQVV 2 27 36
ORF3 HLA-A.02 ALSKGVHFV 3 19 37
ORF3 HLA-A.24 VYFLQSINF 2 28 28
ORF1ab HLA-A.02 KLWAQCVQL 1 21 25
Matrix HLA-B.15 RVAGDSGFAAY 1 22 22
Nucleocapsid HLA-A.02 RTATKAYNV 1 19 23
Matrix HLA-B.07 WPVTLACFV 1 14 21
ORF1ab HLA-A.02 KSVNITFEL 1 16 19
Spike HLA-B.07 SIIAYTMSL 1 15 17
ORF1ab HLA-A.01 PTDNYITTY 1 15 15
ORF1ab HLA-A.02 VMVELVAEL 1 13 17
Spike HLA-DRA.01/B1.04 HWFVTQRNFYEPQII 1 14 14
Matrix HLA-A.02 WLLWPVTLA 1 9 16
ORF14 HLA-A.02 LLLEWLAMA 1 10 13
Nucleocapsid HLA-A.02 LLLDRLNQL 2 4 18
Spike HLA-DRA.01/B1.04 NCTFEYVSQPFLMDL 1 6 16
ORF1ab HLA-A.24 TSQWLTNIF 1 10 11
ORF9b HLA-A.02 KVYPIILRL 1 9 12
ORF1ab HLA-A.02 TLMNVLTLV 1 8 12
ORF1ab HLA-A.02 CLAVHECFV 1 9 10
ORF1ab HLA-A.02 FLLNKEMYL 1 9 10
Spike HLA-B.07 WPWYIWLGF 1 6 13
NSP12 HLA-A.24 VYIGDPAQL 2 9 9
Nucleocapsid HLA-B.44 QELIRQGTDY 1 9 9
ORF1ab HLA-A.02 AIFYLITPV 1 7 11
ORF1ab HLA-A.02 FTVLCLTPV 1 7 11
Spike HLA-DRA.01/B1.11 VGGNYNYLYRLFRKS 1 9 9
ORF1ab HLA-A.02 RQLLFVVEV 1 8 9
ORF1ab HLA-A.24 NYMPYFFTL 1 8 9
ORF3 HLA-A.02 YLYALVYFL 1 7 10
Spike HLA-A.02 RLITGRLQSL 1 9 8
ORF1ab HLA-A.02 KLQFTSLEI 1 8 8
ORF1ab HLA-A.02 YVDNSSLTI 1 7 9
Spike HLA-A.02 VFLVLLPLV 1 7 9
ORF1ab HLA-A.01 NSSTCMMCY 1 6 9
ORF1ab HLA-A.02 FLAHIQWMV 1 6 9
ORF1ab HLA-A.02 KLKDCVMYA 1 7 8
ORF1ab HLA-B.07 MPASWVMRI 1 5 10
ORF1ab HLA-B.07 MPYFFTLLL 1 7 8
Nucleocapsid HLA-A.01 NTNSSPDDQIGYY 1 7 7
Nucleocapsid HLA-B.07 RIRGGDGKM 1 6 8
ORF10 HLA-A.02 NVFAFPFTI 1 7 7
ORF1ab HLA-A.02 FLALCADSI 1 7 7
ORF1ab HLA-A.02 FLPRVFSAV 1 6 8
ORF1ab HLA-A.02 SVLYYQNNV 1 6 8
ORF1ab HLA-A.02 YMPYFFTLL 1 7 7
ORF1ab HLA-A.02 YTMADLVYA 1 5 9
RNP HLA-A.01 DTDFVNEFY 2 6 8
Spike HLA-A.02 IMLCCMTSC 1 6 8
Spike HLA-B.44 AEVQIDRLI 1 7 7
ORF1ab HLA-A.02 FLPGVYSVI 1 5 8
ORF1ab HLA-A.02 LLDDFVEII 1 6 7
ORF1ab HLA-A.02 YVWKSYVHV 1 5 8
ORF7a HLA-B.07 SPIFRIVAA 1 3 10
Spike HLA-DRA.01/B1.15 NLLLQYGSFCTQLNRAL 1 0 13
Matrix HLA-A.24 LWLLWPVTL 1 6 6
NSP3 HLA-A.01 PTDNYITTY 1 4 8
Nucleocapsid HLA-A.02 LLNKHIDAY 1 4 8
ORF1ab HLA-A.02 KLNEEIAII 1 5 7
ORF1ab HLA-A.02 RIMTWLDMV 1 4 8
ORF1ab HLA-A.02 SMMILSDDA 1 6 6
ORF1ab HLA-B.07 SPYNSQNAV 1 4 8
Spike HLA-DRA.01/B1.03 NFSQILPDPSKPSKR 1 6 6
ORF1ab HLA-A.01 YADVFHLYL 1 5 6
ORF1ab HLA-A.02 FLNRFTTTL 1 5 6
ORF1ab HLA-A.02 TLMNVITLV 1 5 6
ORF1ab HLA-A.02 TTIQTIVEV 1 5 6
ORF1ab HLA-A.02 YADVFHLYL 1 5 6
ORF1ab HLA-A.02 YLGGMSYYC 1 5 6
ORF1ab HLA-B.07 VPYFNMVYM 1 4 7
Spike HLA-A.02 FIAGLIAIV 2 4 7
Spike HLA-A.02 KQIYKTPPI 2 5 6
ORF1ab HLA-A.01 FLTENLLLY 1 4 6
ORF1ab HLA-A.01 TSAMQTMLF 1 4 6
ORF1ab HLA-A.02 KLSYGIATV 1 3 7
ORF1ab HLA-A.02 LMCQPILLL 1 4 6
ORF1ab HLA-A.02 LMIERFVSL 1 4 6
ORF1ab HLA-A.02 MLDMYSVML 1 5 5
ORF1ab HLA-A.02 SMWALVISV 1 5 5
ORF1ab HLA-A.02 TLKNTVCTV 1 5 5
ORF1ab HLA-A.02 YLFDESGEF 1 4 6
ORF7a HLA-A.02 KLFIRQEEV 1 5 5
ORF7b HLA-A.02 LLFLVLIML 1 5 5
Spike HLA-A.02 FLHVTYVPA 1 5 5
Spike HLA-DQA1.01/B1.06 NNSYECDIPIGAGIC 1 5 5
Spike HLA-DRA.01/B1.03 RISNCVADYSVLYNS 1 5 5

Self-antigen data

Summary of T-cell receptors recognizing self-antigens, including antigens linked to utoimmune diseases and potential neoantigen targets for cancer immunotherapy. Number of records for self-antigens grouped by (mutated) human gene and corresponding HLAs are plotted using alluvium plot. Only self-antigens with at least 10 records are shown.

Summary of neoantigens and corresponding TCR alpha and beta chain specificity records (cases with 5+ records)

Gene HLA Epitope Studies TRA TRB
MLANA HLA-A.02 ELAGIGILTV 14 354 1413
PGT HLA-A.02 LLAGIGTVPI 1 409 831
BST2 HLA-A.02 LLLGIGILV 1 356 232
MART1 HLA-A.02 ALAGIGILTV 1 90 144
APOB HLA-DRA.01/B1.07 SLFFSAQPFEITAST 1 95 103
IGF2BP2 HLA-A.02 NLSALGIFST 1 0 112
SF3B1 HLA-A.02 RLPGVLPRA 1 40 45
TKT HLA-A.02 AMFWSVPTV 1 0 82
MLANA HLA-A.02 ALGIGILTV 2 33 47
G6PC2 HLA-A.01 LTSLTILQLY 1 33 35
PLA2G6 HLA-A.02 FLASKIGRLV 1 34 34
ZNT8 HLA-B.08 YAKWKLCSA 1 27 40
SEC24A HLA-A.02 FLYNLLTRV 1 0 61
ZNT8 HLA-B.08 YAYAKWKL 1 28 30
MLANA HLA-A.02 EAAGIGILTV 6 13 43
PMEL HLA-A.02 IMDQVPFSV 3 12 44
ZNT8 HLA-A.01 VTDAAHLLI 1 22 32
ZNT8 HLA-A.02 LLSLFSLWL 1 19 32
SLC30A8 HLA-A.02 VAANIVLTV 2 22 27
ZNT8 HLA-A.02 VVTGVLVYL 1 20 26
INS HLA-DQA1.03/B1.02 GQVELGGGNAVEVCK 2 20 20
IAPP HLA-A.01 STNVGSNTY 1 14 25
PORCN HLA-A.02 LLHGFSFYL 1 0 36
GAD2 HLA-B.08 MMIARFKM 1 14 20
GFAP HLA-B.08 HLKRNIVV 1 13 21
IGRP HLA-A.02 FLWSVFWLI 1 12 22
INS HLA-B.08 MALWMRLL 1 15 19
GAD65 HLA-A.02 VMNILLQYV 1 11 21
PMEL HLA-A.02 KTWGQYWQV 1 16 16
PMEL HLA-A.02 YLEPGPVTV 2 1 31
G6PC2 HLA-B.08 NLIFKWIL 1 15 16
WT1 HLA-A.24 CYTWNQMNL 1 15 15
ZNT8 HLA-A.02 IQATVMIIV 1 11 19
PREINS HLA-A.02 ALWMRLLPL 1 13 16
WT1 HLA-A.02 RMFPNAPYL 5 14 14
NY-ESO-1 HLA-DQA.01/B1.07 LLEFYLAMPFATP 1 12 15
IGRP HLA-A.02 VLFGLGFAI 1 9 17
MLANA HLA-A.02 ELAGIGLTV 1 15 11
PREINS HLA-A.02 RLLPLLALL 1 11 14
ZNT8 HLA-A.02 KMYAFTLES 1 7 18
INS HLA-A.01 GSHLVEALY 1 10 14
INS HLA-A.02 RLLPLLALLAL 1 7 16
G6PC2 HLA-B.08 YLKTNLFL 1 8 14
GAD2 HLA-A.01 VSATAGTTVY 1 13 9
IAPP HLA-B.08 ILKLQVFL 1 8 14
ZDBF2 HLA-A.02 YILKYSVFL 1 0 21
AKAP13 HLA-A.02 KLMNIQQKL 1 0 19
NY-ESO-1 HLA-DRA.01/B1.04 PGVLLKEFTVSGNIL 1 9 10
IAPP HLA-A.02 KLQVFLIVL 1 5 13
NY-ESO-1 HLA-A.02 SLLMWITQV 3 9 9
INS HLA-A.24/ LWMRLLPLL 1 6 11
MAGEA1 HLA-A.02 KVLEYVIKV 1 8 8
ADH HLA-A.02 RQFGPDWIVA 1 6 9
FNDC3B HLA-A.02 VVMSWAPPV 1 7 8
GFAP HLA-B.08 LRLRLDQL 1 6 9
PTPRN HLA-A.02 LLPPLLEHL 1 7 8
ZNT8 HLA-A.02 LLSILCIWV 1 5 10
5T4 HLA-A.02 RLARLALVL 1 7 7
BCL2L1 HLA-A.02 YLNDHLEPWI 1 7 7
IGRP HLA-A.02 LNIDLLWSV 1 7 7
IGRP HLA-A.02 NLFLFLFAV 1 4 10
TYR HLA-A.02 CLLWSFQTSA 1 7 7
ZNT8 HLA-A.02 ILSAHVATA 1 7 7
ZNT8 HLA-A.02 LAVDGVLSV 1 8 6
GCN1L1 HLA-A.02 SLLRSLENV 1 0 13
INS HLA-B.08 LWMRLLPL 1 6 7
MLANA HLA-A.02 AAGIGILTV 4 4 9
PTPRN HLA-A.02 VIVMLTPLV 1 5 8
AKAP9 HLA-A.02 RLSDFSEQL 1 0 12
EXOC8 HLA-A.02 IILVAVPHV 1 0 12
GFAP HLA-A.01 ALDIEIATY 1 6 6
SLC3A2 HLA-DRA.01/B1.07 DPPALASTNAEVT 1 6 6
SRPX HLA-A.02 TLWCSPIKV 1 6 6
GAD2 HLA-B.08 SRKHKWKL 1 4 7
GAD2 HLA-B.08 TLKKMREI 1 4 7
INS HLA-B.08 WMRLLPLL 1 4 7
PABPC1 HLA-A.02 MLGEQLFPL 1 0 11
ZNT8 HLA-A.01 PTEKGANEY 1 5 6
GAD2 HLA-A.01 QQDKHYDLSY 1 4 6
GAD2 HLA-B.08 FQQDKHYDL 1 6 4
GANAB HLA-A.02 ALYGFVPVL 1 5 5
NDC1 HLA-A.02 CLNEYHLFL 1 0 10
NY-ESO-1 HLA-B.07 APRGPHGGAASGL 2 5 5
PMEL HLA-A.02 ITDQVPFSV 2 2 8
PTPRN HLA-B.08 HARIKLKV 1 4 6
G6PC2 HLA-B.08 NLIFKWKSI 1 5 4
GAD2 HLA-B.08 EAKQKGFVPF 1 3 6
GAD2 HLA-B.08 HPRYFNQL 1 2 7
GAD2 HLA-B.08 MAALPRLIAF 1 5 4
IGRP HLA-A.02 YLLLRVLNI 1 2 7
INS HLA-A.02 LALWGPDPAA 1 3 6
NRAS HLA-A.01 ILDTAGKEEY 1 4 5
PTPRN HLA-A.02 MVWESGCTV 1 2 7
G6PC2 HLA-A.01 PTHEEHLFY 1 3 5
GAD65 HLA-A.02 ELAEYLYNI 1 5 3
GNL3L HLA-A.02 NLNCCSVPV 1 4 4
IAPP HLA-B.08 LNHLKATPI 1 3 5
INSDRIP HLA-A.02 MLYQHLLPL 1 3 5
PREINS HLA-A.02 HLVEALYLV 1 4 4
RSV-GP HLA-DPA1.01/B1.04 DFHFEVFNFVPCSI 1 4 4
SF3B1 HLA-A.02 ALLPGLPAA 1 4 4
SSX2 HLA-A.02 KASEKIFYV 1 4 4
p53 HLA-A.02 HMTEVVRHC 2 4 4
GAD2 HLA-B.08 RMMEYGTTM 1 4 3
GAD65 HLA-A.02 ILMHCQTTL 1 3 4
KRAS HLA-C.08 GADGVGKSAL 2 3 4
PPM1F HLA-A.02 GVYALIAGA 1 3 4
PTPRN HLA-A.02 SLAAGVKLL 1 3 4
UNC-CDK4-1 HLA-A.02 ALTPVVVTL 1 0 7
ZNT8 HLA-A.02 ILGALLSIL 1 3 4
ZNT8 HLA-A.02 LLIDLTSFL 1 3 4
ZNT8 HLA-A.02 RLLYPDYQI 1 3 4
ASTN1 HLA-A.02 KLYGLDWAEL 1 3 3
CDK4 HLA-A.02 ALDPHSGHFV 1 3 3
GFAP HLA-A.02 NLAQDLATV 1 3 3
GFAP HLA-A.02 QLARQQVHV 1 1 5
IGRP HLA-A.02 FLFAVGFYL 1 2 4
INS HLA-DQA1.03/B1.02 VELGGGPGA 1 3 3
KIF16B HLA-B.07 APARLERRHSA 1 3 3
MMP9 HLA-A.02 NILDAIAEI 1 0 6
PPI HLA-A.02 HLCGSHLVEA 1 1 5
PRPF3 HLA-B.27 TRLALIAPK 1 3 3
PTPRN HLA-A.02 ALTAVAEEV 1 3 3
SMARCD3 HLA-A.02 KLFEFLVYGV 2 3 3
TT HLA-DPA1.01/B1.04 FNNFTVSFWLRVPKVSASHLE 1 3 3
WDR46 HLA-A.02 FLIYLDVSV 1 3 3
gp100 HLA-A.02 YLEPGPVTA 2 3 3
p53 HLA-A.68 SSCMGGMNWR 1 3 3
FGFR3 HLA-A.02 SVCAGILSYGV 1 3 2
G6PC2 HLA-B.08 YVMVTAAL 1 0 5
GAD65 HLA-A.02 LLQEYNWEL 1 3 2
GFAP HLA-B.08 EGHLKRNIV 1 2 3
IGRP HLA-A.02 FLWSVFMLI 1 1 4
PGM5 HLA-A.02 AVGSYVYSV 1 2 3
ZNT8 HLA-A.02 LLMEGVPKSL 1 2 3
ZNT8 HLA-A.02 SISVLISAL 1 3 2

Distribution VDJdb confidence scores

Legend: 0 - low confidence, 1 - medium confidence, 2 - high confidence, 3 - very high confidence.

Note that this scoring system is based on generation probabilities acquired via OLGA model. You might apply alternative methods such as TCRNET to infer high-confidence TCR motifs from VDJdb.


Spectratype

Representative data for Homo Sapiens. CDR3 length distribution (spectratype) is colored by cognate epitope. Second plot shows epitope length distribution for MHC class I and II colored by unique CDR3 (alpha or beta) records.

V(D)J usage and MHC alleles

Representative data for Homo Sapiens, Variable gene. Only Variable genes and MHC alleles with at least 10 records are shown.

Circos plot for correspondence between human TRBV genes and MHC class I alleles for links supported by more than 50 records in terms of the ratio of observed to expected records. Band width and color (from red:highest to light yellow:lowest) are scaled proportional to co-occurrence matrix value divided by row (TRBV) and column (HLA) sums.


Detailed summary for HLA

Representative data for Homo Sapiens MHC class I and II

First chain Second chain Records Unique epitopes Studies
HLA-A*02 B2M 31034 635 131
HLA-A*03 B2M 25432 16 13
HLA-A*11 B2M 4669 9 8
HLA-B*08 B2M 3919 65 22
HLA-A*01 B2M 2871 136 17
HLA-B*07 B2M 2519 120 27
HLA-DRA*01 HLA-DRB1*01 1238 15 12
HLA-A*24 B2M 1007 73 16
HLA-E*01 B2M 729 9 4
HLA-B*27 B2M 687 8 13
HLA-B*57 B2M 659 9 7
HLA-DPA*01 HLA-DPB*04 527 1 2
HLA-DRA*01 HLA-DRB1*04 436 13 9
HLA-DRA*01 HLA-DRB5*01 367 8 7
HLA-B*35 B2M 337 29 22
HLA-B*42 B2M 323 7 5
HLA-DRA1*01 HLA-DRB1*15 301 1 1
HLA-DQA1*05 HLA-DQB1*02 289 17 10
HLA-DRA*01 HLA-DRB1*07 281 10 7
HLA-B*44 B2M 279 9 7
HLA-DRA*01 HLA-DRB1*15 239 9 8
HLA-B*15 B2M 222 6 4
HLA-A*68 B2M 210 4 4
HLA-DRA*01 HLA-DRB1*11 183 5 6
HLA-A*08 B2M 117 1 1
HLA-B*40 B2M 107 3 2
HLA-B*18 B2M 75 9 3
HLA-DQA1*03 HLA-DQB1*02 58 8 3
HLA-DQA1*01 HLA-DQB1*06 49 6 6
HLA-B*81 B2M 44 1 2
HLA-C*07 B2M 43 3 2
HLA-DRA*01 HLA-DRB1*03 38 5 3
HLA-DQA1*02 HLA-DQB1*02 32 6 2
HLA-DRA1*01 HLA-DRB1*11 30 1 1
HLA-B*51 B2M 29 1 1
HLA-DPA1*01 HLA-DPB1*04 28 7 1
HLA-DQA*01 HLA-DRB1*07 27 1 1
HLA-DQA1*03 HLA-DQB1*03 26 8 7
HLA-DQA1*01 HLA-DQB1*02 20 1 1
HLA-DQA1*02 HLA-DQB1*06 20 1 1
HLA-DPA1*02 HLA-DPB1*13 14 1 1
HLA-DQA1*05 HLA-DQB1*03 14 5 3
HLA-C*08 B2M 10 3 3
HLA-DQA1*01 HLA-DQB1*05 10 5 4
HLA-B*53 B2M 9 1 1
HLA-DRA*01 HLA-DRB3*03 9 3 3
DPA1*02 DPB1*05 8 1 1
HLA-B*38 B2M 8 4 2
HLA-A*29 B2M 6 3 1
HLA-DPA1*02 HLA-DPB1*01 6 3 1
HLA-DPA1*02 HLA-DPB1*14 6 3 1
HLA-C*03 B2M 4 2 2
HLA-DPA1*01 HLA-DPB1*02 4 2 2
HLA-DRA*01 HLA-DRB3*02 4 1 1
HLA-A*30 B2M 3 1 1
HLA-DRB1*07 HLA-DRA*01 3 1 1
HLA-A*25 B2M 2 1 1
HLA-B*12 B2M 2 1 1
HLA-B*37 B2M 2 1 1
HLA-B*58 B2M 2 1 1
HLA-C*01 B2M 2 1 1
HLA-C*05 B2M 2 1 1
HLA-C*06 B2M 2 1 1
HLA-DPA1*01 HLA-DPB1*03 2 1 1
HLA-DRA*01 HLA-DRB1*09 2 1 1
HLA-DRA*01 HLA-DRB1*13 2 1 1
HLA-A*32 B2M 1 1 1
HLA-B*14 B2M 1 1 1
HLA-B*52 B2M 1 1 1
HLA-C*04 B2M 1 1 1